Blue Division Standings
| Record | GB | Home | Road | Streak | |
| DeSoto | 0-0 | -- | 0-0 | 0-0 | -- |
| Festus | 0-0 | -- | 0-0 | 0-0 | -- |
| Hillsboro | 0-0 | -- | 0-0 | 0-0 | -- |
| North County | 0-0 | -- | 0-0 | 0-0 | -- |
| Windsor | 0-0 | -- | 0-0 | 0-0 | -- |
◈ - Won District Title
White Division Standings
| Record | GB | Home | Road | Streak | |
| Central | 0-0 | -- | 0-0 | 0-0 | -- |
| Fredericktown | 0-0 | -- | 0-0 | 0-0 | -- |
| Potosi | 0-0 | -- | 0-0 | 0-0 | -- |
| Ste. Genevieve | 0-0 | -- | 0-0 | 0-0 | -- |
| Valle Catholic | 0-0 | -- | 0-0 | 0-0 | -- |
◈ - Won District Title
Other Area Teams
| Record | Home | Road | Streak | |
| Farmington | 0-0 | 0-0 | 0-0 | -- |
◈ - Won District Title
Central Rebels Football
Head Coach: Kory Schweiss • 22nd year| 8/29/2025 | Owensville | @ | Central | |
| 9/5/2025 | Central | @ | Jefferson | |
| 9/12/2025 | Fredericktown | @ | Central | |
| 9/19/2025 | St. Dominic | @ | Central | |
| 9/26/2025 | Central | @ | Ste. Genevieve | |
| 10/3/2025 | Central | @ | Potosi | |
| 10/10/2025 | Valle Catholic | @ | Central | |
| 10/17/2025 | Dexter | @ | Central | |
| 10/24/2025 | Central | @ | Farmington |
DeSoto Dragons Football
Head Coach: Russ Schmidt • 3rd year| 8/29/2025 | DeSoto | @ | Freeburg, IL | |
| 9/5/2025 | DeSoto | @ | Perryville | |
| 9/12/2025 | North County | @ | DeSoto | |
| 9/19/2025 | Festus | @ | DeSoto | |
| 9/26/2025 | DeSoto | @ | Windsor | |
| 10/3/2025 | Fredericktown | @ | DeSoto | |
| 10/10/2025 | DeSoto | @ | Hillsboro | |
| 10/17/2025 | Potosi | @ | DeSoto | |
| 10/24/2025 | DeSoto | @ | Herculaneum |
Farmington Knights Football
Head Coach: Brent Eckley • 1st year| 8/29/2025 | North County | @ | Farmington | |
| 9/5/2025 | Farmington | @ | St. Clair | |
| 9/12/2025 | Poplar Bluff | @ | Farmington | |
| 9/19/2025 | Jackson | @ | Farmington | |
| 9/26/2025 | Farmington | @ | Sikeston | |
| 10/3/2025 | Union | @ | Farmington | |
| 10/10/2025 | Farmington | @ | Cape Central | |
| 10/17/2025 | Farmington | @ | Festus | |
| 10/24/2025 | Central | @ | Farmington |
Festus Tigers Football
Head Coach: AJ Ofodile • 6th year| 8/29/2025 | Festus | @ | Rolla | |
| 9/5/2025 | Francis Howell Central | @ | Festus | |
| 9/12/2025 | Windsor | @ | Festus | |
| 9/19/2025 | Festus | @ | DeSoto | |
| 9/26/2025 | Hillsboro | @ | Festus | |
| 10/3/2025 | Festus | @ | North County | |
| 10/10/2025 | Festus | @ | DeSmet Jesuit | |
| 10/17/2025 | Farmington | @ | Festus | |
| 10/24/2025 | Jackson | @ | Festus |
Fredericktown Blackcats Football
Head Coach: Steve Williams • 3rd year| 8/29/2025 | Perryville | @ | Fredericktown | |
| 9/5/2025 | Fredericktown | @ | Herculaneum | |
| 9/12/2025 | Fredericktown | @ | Central | |
| 9/19/2025 | Fredericktown | @ | Valle Catholic | |
| 9/26/2025 | Potosi | @ | Fredericktown | |
| 10/3/2025 | Fredericktown | @ | DeSoto | |
| 10/10/2025 | Ste. Genevieve | @ | Fredericktown | |
| 10/17/2025 | Windsor | @ | Fredericktown | |
| 10/24/2025 | East Prairie | @ | Fredericktown |
Hillsboro Hawks Football
Head Coach: Bill Sucharski • 6th year| 8/29/2025 | Hillsboro | @ | Moberly | |
| 9/5/2025 | SLUH | @ | Hillsboro | |
| 9/12/2025 | Hillsboro | @ | Washington | |
| 9/19/2025 | Hillsboro | @ | North County | |
| 9/26/2025 | Hillsboro | @ | Festus | |
| 10/3/2025 | Windsor | @ | Hillsboro | |
| 10/10/2025 | DeSoto | @ | Hillsboro | |
| 10/17/2025 | Chaminade | @ | Hillsboro | |
| 10/24/2025 | Hillsboro | @ | Poplar Bluff |
North County Raiders Football
Head Coach: Brian Jones • 9th year| 8/29/2025 | North County | @ | Farmington | |
| 9/5/2025 | North County | @ | Glenwood, IL | |
| 9/12/2025 | North County | @ | DeSoto | |
| 9/19/2025 | Hillsboro | @ | North County | |
| 9/26/2025 | Rolla | @ | North County | |
| 10/3/2025 | Festus | @ | North County | |
| 10/10/2025 | North County | @ | Windsor | |
| 10/16/2025 | North County | @ | St. Clair | |
| 10/23/2025 | Sullivan | @ | North County |
Potosi Trojans Football
Head Coach: Mark Casey • 1st year| 8/29/2025 | Potosi | @ | St. Clair | |
| 9/5/2025 | Potosi | @ | Charleston | |
| 9/12/2025 | Potosi | @ | Valle Catholic | |
| 9/19/2025 | Ste. Genevieve | @ | Potosi | |
| 9/26/2025 | Potosi | @ | Fredericktown | |
| 10/3/2025 | Central | @ | Potosi | |
| 10/10/2025 | Pacific | @ | Potosi | |
| 10/17/2025 | Potosi | @ | DeSoto | |
| 10/24/2025 | Potosi | @ | St. Charles West |
Ste. Genevieve Dragons Football
Head Coach: Jay Pope • 5th year| 8/29/2025 | St. Vincent | @ | Ste. Genevieve | |
| 9/5/2025 | Ste. Genevieve | @ | University City | |
| 9/12/2025 | Ste. Genevieve | @ | Kennett | |
| 9/19/2025 | Ste. Genevieve | @ | Potosi | |
| 9/26/2025 | Central | @ | Ste. Genevieve | |
| 10/3/2025 | Valle Catholic | @ | Ste. Genevieve | |
| 10/10/2025 | Ste. Genevieve | @ | Fredericktown | |
| 10/17/2025 | Jefferson | @ | Ste. Genevieve | |
| 10/24/2025 | Caruthersville | @ | Ste. Genevieve |
Valle Catholic Warriors Football
Head Coach: Judd Naeger • 21st year| 8/29/2025 | Monroe City | @ | Valle Catholic | |
| 9/5/2025 | Valle Catholic | @ | St. Vincent | |
| 9/12/2025 | Potosi | @ | Valle Catholic | |
| 9/19/2025 | Fredericktown | @ | Valle Catholic | |
| 9/26/2025 | Valle Catholic | @ | Caruthersville | |
| 10/3/2025 | Valle Catholic | @ | Ste. Genevieve | |
| 10/10/2025 | Valle Catholic | @ | Central | |
| 10/17/2025 | Bowling Green | @ | Valle Catholic | |
| 10/24/2025 | St. Pius | @ | Valle Catholic |
Windsor Owls Football
Head Coach: Lee Freeman • 2nd year| 8/29/2025 | Herculaneum | @ | Windsor | |
| 9/5/2025 | Affton | @ | Windsor | |
| 9/12/2025 | Windsor | @ | Festus | |
| 9/19/2025 | Windsor | @ | Clayton | |
| 9/26/2025 | DeSoto | @ | Windsor | |
| 10/3/2025 | Windsor | @ | Hillsboro | |
| 10/10/2025 | North County | @ | Windsor | |
| 10/17/2025 | Windsor | @ | Fredericktown | |
| 10/24/2025 | Bayless | @ | Windsor |